Dengue is one of the most important arthropod-borne viral diseases with large global burden. The
disease is caused by dengue virus (DENV), a member of Flaviviridae family, with four distinct
serotypes (DENV-1, -2, -3, and -4) circulating in tropical and subtropical regions in the world.
DENV is transmitted to human by Aedes mosquitoes as vector. Dengue clinical manifestations
vary from asymptomatic or mild flu-like syndrome known as classic Dengue Fever (DF) to more
severe form known as Dengue Hemorrhagic Fever (DHF) and the potentially fatal Dengue Shock
Syndrome (DSS). Similar to other RNA viruses, DENV possess diverse genetic characteristics as
shown by the presence of various genotypes within serotypes.