Cervical cancer (CC) is one of the most widely spread oncological pathologies that ranks second by the incidence in women in the world. Each year about 600 thousand of new CC cases are registered in the world with more than 250 thousand lethal outcomes. The virus nature of this cancer is confirmed by the World Health Organization and HPV is detected practically in 100 percent of cases of cervical precancer and cancer. Based on the frequency of detection of HPV genotypes from different grades of Cervical Intraepithelial Neoplasia (CIN Grades I-III), HPV genotypes are subdivided into High-risk HPV types (16, 18, 31 and 45), Intermediate-risk types (33, 35, 39, 51, 52, 56, 58, 59, and 68), and Low-risk types (6, 11, 42-44). Owing to the fact that the cervical cancer (CC) has a long development period and a fail-safe recognizable pre-clinic phase there is a possibility to detect and prevent the disease on its early stage.
Products
PCR Kits for screening of high carcinogenic risk HPV genotypes
The kit HPV High Risk Screen Real-TM Quant is an in vitro Real Time amplification test for quantitative detection of 12 types of HPV (16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59). It being known, that the parameter of viral load has a prognostic value and the viral load less than 10*5 HPV genomic equivalents in the swab or 10*3 genomic equivalents for 10*5 cells is considered as insignificant and indicates the presence of transitory infection, however such level of load may have a value only in cases of treatment monitoring. Viral load of more than 10*5 genomic equivalents for 10*5 cells is considered to be important with high significance and indicates the existence of dysplastic changes or high risk of their occurrence. Quantitative detection of viral load allows to evaluate the character of the infection and to make a forecast concerning the stage of the disease.
Kit
Description
N. test
Code
HPV 14 Screening & 16,18, 45 Typing Real-TM Quant
Real Time PCR kit
Real Time PCR kit for quantitative detection and genotyping of Human Papillomavirus types 16,18,45 and quantitative detection of HPV types 31, 33, 35, 39, 51, 52, 56, 58, 59, 66, 68
100
V31-100/F FRT
HPV High Risk Screen Real-TM Quant
Real Time PCR kit
Real Time Amplification test for quantitative detection of Human Papillomavirus (16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59)
100
V31-100/2FRT
HPV High Risk Screen Real-TM Quant 2X
Real Time PCR kit
Real Time amplification test for quantitative detection of Human Papillomavirus (16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59) on two-channels devices
100
V31-100/2FRT 2x
PCR Kits for typing of high carcinogenic risk HPV genotypes
The kit HPV High Risk Typing Real-TM is an in vitro multiplex Real Time amplification test for qualitative detection and genotyping of Human Papillomavirus (16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59) in the urogenital swabs and biopsies. The kit HPV High Risk Typing Real-TM is based on two major processes: isolation of DNA from specimens and multiplex Real Time amplification of 4 tubes for each sample. Each tube contains primers directed against regions of three HPV types and beta-globine gene used as Internal Control.
Kit
Description
N. test
Code
HPV Genotypes 14 Real-TM Quant
Real Time PCR kit
Real Time PCR Kit for quantitative detection and genotyping of Human Papillomavirus (16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66 and 68)
100
V67-100FRT
HPV 16/18 Real-TM Quant
Real Time PCR kit
Real Time Amplification test for quantitative detection and genotyping of Human Papillomavirus (16, 18)
100
V12-100FRT
HPV Genotypes 21 Real-TM Quant
Real Time PCR kit
Real Time PCR kit for identification, typing and quantification of Human Papillomavirus types low-risk (HPV 6, 11, 44) and high- risk (HPV 16, 18, 26, 31, 33, 35, 39, 45, 51, 52, 53, 56, 58, 59, 66, 68, 73, 82)
96
V21-100 FRT
PCR kits for Low carcinogenic risk HPV
A group of low carcinogenic risk HPV is represented by more than 12 genotypes and they are called Low Risk because they cannot cause cervical cancer. Sometimes low-risk HPV types can cause visible changes in the genital area, called genital warts. Genital warts are growths or bumps in the genital areas of men and women. They usually are painless. They may be raised, flat, small or large, and single or multiple. Among low risk HPV the genotypes 6 and 11 are of greatest importance as they are responsible for the overwhelming amount of low-carcinogenic pointed condylomas of genital organs and for more than 90 percent of cases of condylomatosis of the larynx in children.
Kit
Description
N. test
Code
HPV 6/11 Real-TM
Real Time PCR kit
Real Time amplification test for qualitative detection of Human Papillomavirus 6 and 11
